Noopept vs Piracetam Comparison: What’s The Difference?


Image result for noopept wikipedia

  • Improves Cognition, Memory, and Concetration
  • Strong Neuroprotective Properties
  • Promotes the Production of neurons in the brain
  • Fast-acting (15 minutes)
  • Reduces brain fog
  • Used for treating Dementia and Alzheimers
  • Used in the Treatment of Stroke Patients
  • Prevents Cognitive Decline
  • Increases mental stamina and attention span
  • Higher Bioavailability Than Piracetam
  • First developed in 1996

Noopept is Great for Experienced Nootropics Users Looking for Something More Potent Than Piracetam


Image result for piracetam wikipedia

  • Improves Memory, Cognition, and Concentration
  • Improves Cellular Membrane Fluidity
  • More Widely Used Than Noopept
  • Prevents Cognitive Decline
  • Used for treating Dementia and Alzheimers
  • Reduces brain fog
  • Generally Milder Side Effects
  • Lower Bioavailability Than Noopept
  • Low Toxicity Profile (few side effects)
  • Potentially Effective for People with ADHD
  • First developed in 1996

Piracetam is Usually Better for Beginner Nootropics Users, But is Often The Go-To Racetam for Experienced Nootropics Users as Well.

Some background for those who are new to Nootropics: Nootropics are drugs that boost the mental abilities of those who use them. Many fans of nootropics have improved their lives significantly through the use of these drugs. With Nootropics you can see benefits to mental cognition, memory, learning ability, wakefulness, motivation, energy, sleep quality, and anxiety levels. 

While some people use Nootropics to target specific issues, a healthy person that does not suffer from depression, anxiety, or difficulty concentrating may still benefit from nootropics. Nootropics can, within reason, boost your mental stamina and intelligence which is tremendously beneficial for activities such as work, studying, gaming, programming, exercising, or competing in athletics. 

If you are interested in trying nootropics, you may be overwhelmed by the number of different nootropics available to try. What are the most effective nootropics, and the safest? Where should you start? Two of the best options for beginners interested in effective, completely legal nootropics are Noopept and Piracetam. Both of these supplements can boost your abilities above normal. People who use Noopept and Piracetam are usually seeking a boost to their mental capacity, memory, and cognition though there are other purported medical uses and benefits.

What is Noopept?

Discovered in Russia in 1996 [1], Noopept, the brand name for N-phenylacetyl-L-prolylglycine ethyl ester, is an extremely potent nootropic substance that has a powerful effect even in tiny doses. Only milligrams of Noopept are required to have the same effect as entire grams of Piracetam. The molecular structures of Noopept and Piracetam are quite similar, but Noopept is more efficient at passing through the blood-brain barrier, making it much more potent in small doses than Piracetam.

Studied Benefits: Noopept has been shown in studies to have benefits and effects similar to those of Piracetam, but at a smaller dose. Additionally, Noopept has shown strong neuroprotective properties in cases of brain trauma and injury, outperforming Piracetam.

Anecdotal Benefits: Noopept works well for students and others that want to remember a large amount of information or learn a new skill in a short time as noopept can increase cognition, memory, and improve learning. Noopept users commonly report better retention of information when reading or learning a new skill. Noopept also makes it much easier to recall information you already know but would otherwise find it hard to remember.

The quality of your conversations may also improve with Noopept. Mental stamina can significantly increase, with users being able to concentrate for much longer times. Brain fog will often disappear for those using Noopept. Someone who is only unreliably capable of difficult mental or creative tasks can become reliably capable of them by using Noopept to get rid of their brain fog. Improved attention span is yet another commonly reported benefit of Noopept.

In some cases, noopept can help relieve symptoms of depression and anxiety, though this is not its primary purpose. Since Noopept improves the overall functioning of the brain, it can improve your mood as well as your concentration.

How Does Noopept work?

After being taken, the intestines digest the drug, and it passes from there into the brain. Noopept does not have trouble passing the blood-brain barrier [C]. The blood vessels that control what is allowed into the brain do not reject Noopept. It’s ability to efficiently cross the blood-brain barrier makes it a fast-acting and effective drug. Noopept only takes fifteen or twenty minutes to “kick-in”.

Noopept works by preventing glutamate from being broken down. (Glutamate is a naturally occurring, abundant excitatory neurotransmitter found in the brain). Noopept prevents the brain from breaking down glutamate, causing glutamate levels to increase. Noopept is also believed to make glutamate receptors more sensitive increase the amount of oxygen in the brain. Noopept also helps the brain to use sugar more effectively.

Can Noopept treat dementia?

Like many other nootropics, Noopept may help those who have dementia. If the blood-brain barrier is not functioning correctly, harmful chemicals may enter the brain. These chemicals include beta-amyloid compounds. A buildup of these chemicals can contribute to Alzheimer’s disease. There is some evidence that Noopept protects the brain from these harmful chemicals and may be able to help those with dementia.

The Benefits of Piracetam

Piracetam, invented in 1964, has been around for a considerably longer period of time than Noopept. In the world of pharmaceuticals, the longer a drug has been around, the longer there has been to test it clinically, which can help verify the drug’s safety, risks, and benefits. Piracetam remains legal without a prescription in the United States after over fifty years for clinical testing and individual use.

Like Noopept, Piracetam is primarily what we will call a “brain booster”. Piracetam affects the Acetylcholine system by making Acetylcholine receptors more sensitive. Acetylcholine is a neurotransmitter that is vital for brain function. While Piracetam does not raise levels of Acetylcholine in the brain as some other nootropics do, Piracetam allows the neurotransmitter to have a more significant effect. Piracetam also increases oxygen and improves glucose metabolism in the brain.

Another mechanism by which Piracetam works is by making cell membranes more permeable. Since cells communicate with each other through chemicals, increased cell membrane permeability makes cells send more chemical messages to each other. The process of thinking speeds up if cells can communicate with each other more effectively in the brain.

Even after half a century’s worth of use, Piracetam is still not completely understood, as is common with many drugs that affect the brain. The effects of the Piracetam are widely accdepted to be significant, but there is still only a partial understanding of the mechanisms of action with which Piracetam affects the brain. Some studies point to the benefits of Piracetam being due to improved circulation in the brain and due to cells being able to eliminate waste more effectively.

Piracetam has had much longer to establish a reputation than Noopept and is a drug that is commonly used and recommended among notoropics users. The total number of diseases that Piracetam can effectively treat is not known, though the drug has been studied as a treatment for a wide range of mental, physical, and behavioral problems. There is anecdotal evidence to suggest it may help those with anything from alcohol addiction or ADHD to sickle cell anemia [X]. Healthy people often use the drug to study, remember information, or help learn new skills. Many people also use Piracetam to boost their social intelligence. When a person tries Piracetam, one of the first things they often notice is that colors seem noticeably more vivid, sounds are sharper, and conversations flow more naturally.

Noopept vs Piracetam: A Nootropics Comparison

Piracetam is a nootropic of the racetam class, a group of drugs that work by making the brain more sensitive to acetylcholine (in addition to other effects). Noopept, on the other hand, is not technically a racetam because it does not have a 2-oxo-pyrollidine skeleton, but is commonly lumped in with the racetams group. It works primarily by increasing the amount of glutamate in the brain. Which of the two drugs is more effective depends on the individual that uses them. Fans of nootropics are likely to have tried both of these drugs as they are both commonly used.

Noopept vs Piracetam: Potency

Noopept is a much more potent substance than Piracetam. Noopept is a thousand or more times stronger than Piracetam is. It does not have a thousand times the effect on a user because the typical dose of Noopept is vastly less than a standard treatment of Piracetam. A tiny dose of Noopept may have more of an effect than a similar dose of any other nootropic.

Noopept vs Piracetam: Bioavailability

When one takes a drug, most of it usually passes through the body without affecting the body in any way. The body tends to use only a small amount of a drug. If the body uses a relatively large amount of a drug, the drug is said to have high bioavailability. Low bioavailability means that the body uses only a tiny amount of the drug.

A high percentage of Piracetam mostly passes through your system without having any effect on the body, and therefote requires a higher dose to be effective. Noopept, on the other hand, is more effective at passing through the blood-brain barrier and much less is wasted through your digestive system. Part of Piracetam’s higher potency comes from its higher bioavailability.

Noopept vs Piracetam: Side effects

Both drugs are generally considered by most nootropics users to be safe when taken responsibly by healthy individuals in appropriate dosages. People have been using Noopept for ten and Piracetam for fifty years without either drug becoming illegal or prescription only in the United States. First-time users of either drug may find it an unpleasant experience. Taking more than a little the first time one uses the drug can lead to headaches and nervousness.

Most of those who use Noopept experience few if any side effects. Side effects are more likely when taking a stronger dose than stadnard dose of Noopept. If side effects do appear, they tend to be mild. Some of the more unpleasant potential side effects of the drug are diarrhea and nausea.

It is also possible for Noopept to worsen your ability to think or sour your mood instead of improving your mood and thinking for some users [2]. Taking too much of the drug can result in the opposite of the intended effects for some users.

Physical weakness is another problem that Noopept can cause, and it can cause memory loss as well [3]. If you find yourself unable to complete a physical task that took only moderate effort before, you may have to stop using the drug. Noopept has been anecdotally reported to induce weight loss through affecting appetite. Weight loss is more common than weight gain, but weight gain has been reported by some users as well. The drug can either raise or lower appetite. Visual hallucinations have been reported by those who take massive quantities of the drug. Usually, users do not experience any unpleasant side effects when taking Noopept. The drug has only its intended results for most users.

Both Piracetam and Noopept are popular nootropics, however, people have been using Piracetam for a much longer period of time. In theory, this makes it the safer choice between the two drugs as there has been more time for serious issues to present themeselves if there are any. Piracetam side effects are generally not long-lasting or dangerous. While Noopept is more likely to cause weight loss, Piracetam is more likely to lead to weight gain. Diarrhea sometimes occurs, as well as nervousness, insomnia, and muscle spasms. Like Noopept, Piracetam can interfere with rather than improve clear thinking for some of its users.

Noopept vs Piracetam: Dosage

Those who use Piracetam take anywhere from 1-5 grams each day. New users should be careful with higher doses. Noopept doses are only 10-30 milligrams per day.

Noopept vs Piracetam: Combining with other Nootropics

Most fans of Nootropics combine different supplements and use different supplements for different situations. They might also temporarily stop using each supplement periodically to avoid developing a tolerance for any supplement.

One combination of supplements that Nootropics users widely recommend is a combination of Piracetam (or any other racetam class nootropic) and any nootropic that boosts acetylcholine. Supplements such as CDP Choline and Alpha-GPC raise levels of acetylcholine in the brain. Since racetams make the brain more sensitive to acetylcholine, combining CDP Choline and Piracetam can give you a very high amount of mental energy. Combining the two drugs may also reduce rather than increase the risk of side effects.

One might also combine Piracetam with Noopept, as both drugs have differentmechanisms of action, though this is not something that is particularly recommended as both drugs have similar cognitive effects. Some Nootropics users have reported combining all three drugs (Piracetam, Noopept, and an acetylcholine raising supplement such as Citicoline or Alpha-GPC) for a particularly potent mental energy boost. Again, this is not recommended, especially for those new to nootropics.

Noopept vs Piracetam: Treating Alzheimers and ADHD

There is some evidence, both clinical and anecdotal, that Piracetam may help those who have Alzheimer’s disease and other forms of dementia. The evidence is not, however, strong enough for doctors to frequently recommend the drug. Higher doses of Piracetam are needed to treat dementia. A study of the effects of Piracetam on older people with significant cognitive decline found 4.8 grams per day to improve memory beyond 2.4 grams per day or placebo [4]. Alzheimer’s disease involves acetylcholine [4], and Piracetam may, therefore, reduce the severity of the disease.

Since Piracetam can boost a person’s cognitive power in general, you might choose to take it if you have Attention Deficit Disorder. Drugs such as Ritalin and Adderall can be harmful and addictive. If Piracetam works just as well for you as Adderall, you may consider talking to you doctor about replacing you Adderall prescription with Piracetam. There is some medical evidence in favor of Piracetam in combination with Atomoxetine for the treatment of ADD [5]. However, the evidence is limited so far. The drug is not yet recommended by doctors for the treatment of ADD.

Evidence for or against Noopept as a treatment for ADD or Dementia is also limited. There is only some not yet conclusive evidence in favor of the drug being a treatment for Alzheimer’s [6], but it is not, however, enough for doctors to recommend it.

Noopept vs Piracetam: Overall

Either drug may work better for you. Since Piracetam is decades older than Piracetam, its safety is more likely. Additionally, Piracetam’s side effects are generally milder than those of Noopept. Piracetam can also be particularly useful if it is combined with a supplement that raises Choline. For these reasons it is probably better than (the potentially stronger and cheaper) Noopept and should be tried first by new Nootropics users.




[4] Wingbald, Bengt (2005). Piracetam: A Review of Pharmacological Properties and Clinical Uses. Retrieved from:

[5] Zavadenko, N. N., & Suvorinova, N. I. (2008). [Atomoxetine and piracetam in the treatment of attention deficit hyperactivity disorder in children]. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova / Ministerstvo Zdravookhraneniia I Meditsinskoi Promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe Obshchestvo Nevrologov [i] Vserossiiskoe Obshchestvo Psikhiatrov, 108(7), 43–47.